Welcome to the RESTORE Study Website!
The Randomized Evaluation of Sedation Titration fOr Respiratory failurE is an NIH sponsored study at 31 pediatric intensive care units across the United States. The purpose of the study is to evaluate if sedatives used in children with acute respiratory failure affects how long they need to be mechanically ventilated, how much it costs, and their quality of life and emotional health after hospital discharge.
Ensuring the safety and comfort of critically ill infants and children supported on mechanical ventilation is integral to the practice of pediatric critical care. Yet, the medications required to keep patients comfortable and safe can cause other complications. Over time, children can develop a tolerance to the sedation medications and may experience undesired side effects requiring them to remain on the ventilator longer.
Using a protocol or guideline to manage sedation may allow some pediatric patients to come off the ventilator faster with fewer side effects because less medication is used. The study will include physician and nurse training and daily agreement on sedation goals and management when children are ventilated.
This study is being done to learn more about the best ways to keep children comfortable and safe during mechanical ventilation, while limiting undesired short-term and long-term risks.